Here we attempt to narrate twenty years dedicated to the continuous pursuit of significant ideas in the exploration of 6 “good design” projects. Exploration that starts by analysing new and apparently distant topics, yet each developed by continuously balancing the humanistic and scientific approaches. 6 designs are narrated from their conception to their birth as finished products and are introduced by the “Six memos for the next millennium”, taken from the unforgettable “Lezioni Americane”, written by Italo Calvino, a work which inspired our projects and this publication.